Detection of cell density

Across TCGA patient cohorts, RNA activity of the Detection of cell density pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MSRB3, BMP4, and HABP4, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of cell density activity versus MSRB3 in BRCA (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	MSRB3 →	+0.827	+0.148	.001	.001	3	5
BRCA	BMP4 →	+0.826	+0.153	<.001	<.001	3	5
BRCA	HABP4 →	+0.430	+0.156	<.001	<.001	3	5
BRCA	ANTXR1 →	+0.793	+0.168	.003	<.001	3	5
COAD	WASH2P →	+0.497	+0.850	<.001	<.001	3	5
UCEC	AP4B1 →	+0.494	+0.203	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060245 vs MSRB3 — BRCA

Explore this scatter interactively →