Detection of cell density

Across TCGA patient cohorts, RNA activity of the Detection of cell density pathway is significantly associated with the protein abundance of multiple proteins, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UNC119B, C9orf78_S261, and EFEMP2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of cell density activity versus UNC119B in COAD (Pearson r = 0.39).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	UNC119B →	+0.515	+0.968	<.001	<.001	3	3
OV	C9orf78_S261 →	-1.115	-0.635	<.001	<.001	3	3
PDAC	EFEMP2 →	+0.492	+0.145	<.001	<.001	3	3
PDAC	FSTL1 →	+0.449	+0.191	<.001	<.001	3	3
GBM	KRT18 →	+0.827	+0.182	<.001	<.001	3	3
LUAD	PHC3_S263 →	-0.397	-0.207	<.001	.003	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060245 vs UNC119B — COAD

Explore this scatter interactively →