Detection of cell density

Across TCGA cell cohorts, RNA activity of the Detection of cell density pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LATS2, STK3, and PTPRJ, each associated with the pathway in up to 13 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of cell density activity versus LATS2 in LARGE_INTESTINE (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LATS2 →	+1.234	+0.136	<.001	<.001	3	13
LIVER	STK3 →	+1.123	+0.177	<.001	<.001	3	12
BONE	PTPRJ →	+1.711	+0.111	<.001	<.001	3	11
LARGE_INTESTINE	TIMP2 →	+3.490	+0.100	<.001	<.001	3	11
LARGE_INTESTINE	TEAD1 →	+1.514	+0.105	<.001	<.001	3	10
LIVER	RECK →	+1.670	+0.139	.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060245 vs LATS2 — LARGE_INTESTINE

Explore this scatter interactively →