Detection of cell density

Across TCGA cell cohorts, RNA activity of the Detection of cell density pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTPRJ, ZNF561, and ENDOD1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Detection of cell density activity versus PTPRJ in OVARY (Pearson r = 0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	PTPRJ →	+1.915	+1.085	<.001	.001	3	5
BLOOD_Lymphoma	ZNF561 →	+0.625	+0.591	.002	.008	3	4
OVARY	ENDOD1 →	+1.080	+0.876	.003	.002	3	4
PANCREAS	CEP57 →	+0.639	+0.805	.003	.003	3	4
BREAST	GDF15 →	+2.852	+0.469	.001	<.001	3	3
BREAST	CETN3 →	+0.703	+0.392	.005	.007	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060245 vs PTPRJ — OVARY

Explore this scatter interactively →