Delamination

Across TCGA patient cohorts, RNA activity of the Delamination pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are WIPF1, CD48, and CORO1A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Delamination activity versus WIPF1 in OV (Pearson r = 0.57).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WIPF1 →	+0.615	+0.079	<.001	<.001	3	8
OV	CD48 →	+0.873	+0.083	.002	<.001	2	9
OV	CORO1A →	+0.740	+0.080	<.001	<.001	3	8
OV	DOCK2 →	+0.727	+0.090	<.001	<.001	3	8
GBM	DOCK8 →	+0.463	+0.113	<.001	<.001	3	8
OV	ELMO1 →	+0.533	+0.085	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060232 vs WIPF1 — OV

Explore this scatter interactively →