Retinal rod cell differentiation

Across TCGA patient cohorts, RNA activity of the Retinal rod cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are DOCK11, STK4, and RENBP, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal rod cell differentiation activity versus DOCK11 in OV (Pearson r = -0.17).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	DOCK11 →	-0.444	-0.053	<.001	<.001	3	7
LSCC	STK4 →	-0.360	-0.073	<.001	<.001	3	6
OV	RENBP →	-0.388	-0.049	.004	<.001	3	6
BRCA	WIPF1 →	-0.336	-0.057	<.001	<.001	3	6
HNSC	ARHGAP25 →	-0.574	-0.078	<.001	<.001	3	6
LSCC	FNBP1 →	-0.436	-0.089	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060221 vs DOCK11 — OV

Explore this scatter interactively →