Retinal rod cell differentiation

Across TCGA patient cohorts, RNA activity of the Retinal rod cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are UBE2D2, NADK2-AS1, and PPP1R13L, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Retinal rod cell differentiation activity versus UBE2D2 in PDAC (Pearson r = 0.29).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	UBE2D2 →	+0.249	+0.191	<.001	<.001	3	4
PDAC	NADK2-AS1 →	+0.489	+0.224	.006	<.001	3	4
BRCA	PPP1R13L →	+0.676	+0.509	.001	.008	3	4
CCRCC	PRKCSH →	+0.348	+0.128	<.001	.005	3	4
BRCA	MZF1-AS1 →	+0.475	+0.628	.001	.001	3	4
BRCA	KDELR1 →	+0.268	+0.545	.006	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060221 vs UBE2D2 — PDAC

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