Retinal rod cell differentiation

Across TCGA cell cohorts, RNA activity of the Retinal rod cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNKS, PLCG2, and METTL5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TNKS grouped by Retinal rod cell differentiation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TNKS →	-0.779	-1.412	.001	.004	3	5
PANCREAS	PLCG2 →	+1.385	+1.004	.001	.006	3	4
LUNG_SCLC	METTL5 →	+0.678	+1.428	.002	<.001	3	4
LUNG_SCLC	VMP1 →	+1.676	+1.517	.001	.001	3	4
LIVER	MCPH1 →	-0.778	-1.739	.008	.008	2	5
OVARY	B3GNT3 →	+2.360	+1.078	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TNKS by Retinal rod cell differentiation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →