Retinal rod cell differentiation

Across TCGA cell cohorts, RNA activity of the Retinal rod cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SESN1, UBL3, and ASZ1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, SESN1 grouped by Retinal rod cell differentiation-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	SESN1 →	-0.113	-0.456	.002	.003	3	3
OESOPHAGUS	UBL3 →	-0.200	-1.502	.001	<.001	3	3
OESOPHAGUS	ASZ1 →	+0.252	+1.845	.009	<.001	3	3
LUNG_SCLC	LINC00504 →	-0.137	-1.804	.003	<.001	3	3
BLOOD_Leukemia	ACTR3B →	-0.165	-1.144	<.001	<.001	3	3
STOMACH	TGOLN2 →	+0.375	+0.111	.004	.008	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

SESN1 by Retinal rod cell differentiation activity — BREAST

Explore this box plot interactively →