Camera-type eye photoreceptor cell differentiation

Across TCGA patient cohorts, RNA activity of the Camera-type eye photoreceptor cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are GMIP, LIN7C, and IKZF1_S445, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Camera-type eye photoreceptor cell differentiation activity versus GMIP in LSCC (Pearson r = -0.26).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GMIP →	-0.333	-0.077	<.001	<.001	3	8
LSCC	LIN7C →	+0.197	+0.043	.006	.002	3	7
OV	IKZF1_S445 →	-1.285	-0.033	.008	.008	3	7
HNSC	RASAL3 →	-0.449	-0.060	<.001	<.001	3	7
LSCC	TRPV2 →	-0.299	-0.056	<.001	<.001	3	6
UCEC	STAT2 →	-0.333	-0.054	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060219 vs GMIP — LSCC

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