Camera-type eye photoreceptor cell differentiation

Across TCGA patient cohorts, RNA activity of the Camera-type eye photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PABPC4L, RPL13AP25, and PGRMC2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Camera-type eye photoreceptor cell differentiation activity versus PABPC4L in LUAD (Pearson r = 0.15).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	PABPC4L →	+0.465	+0.180	<.001	.001	3	4
LSCC	RPL13AP25 →	+0.329	+0.240	.009	.004	3	3
LSCC	PGRMC2 →	+0.313	+0.243	.002	.006	3	3
LSCC	LINC00308 →	+0.633	+0.181	.006	.007	3	3
OV	DNAJB9 →	+0.673	+0.733	<.001	.001	3	3
PDAC	MAEL →	+0.268	+0.153	.004	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060219 vs PABPC4L — LUAD

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