Camera-type eye photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Camera-type eye photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CYP24A1, TMEM126B, and FANCL, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CYP24A1 grouped by Camera-type eye photoreceptor cell differentiation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CYP24A1 →	+2.712	+0.871	<.001	.004	3	4
LUNG_NSCLC_LUSC	TMEM126B →	+0.621	+1.301	.005	.003	3	4
KIDNEY	FANCL →	+0.785	+1.244	.001	.001	3	4
BREAST	CIR1 →	+0.466	+0.887	<.001	<.001	3	4
SOFT_TISSUE	FCGRT →	+2.928	+1.280	.001	.001	3	4
PANCREAS	PSMC6 →	+0.559	+1.293	.009	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CYP24A1 by Camera-type eye photoreceptor cell differentiation activity — PANCREAS

Explore this box plot interactively →