Camera-type eye photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Camera-type eye photoreceptor cell differentiation pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CPLANE2, NXF3, and ATXN7, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CPLANE2 grouped by Camera-type eye photoreceptor cell differentiation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	CPLANE2 →	-0.163	-1.193	.003	.004	3	3
BREAST	NXF3 →	-0.100	-0.632	.009	<.001	3	3
BREAST	ATXN7 →	+0.184	+0.869	<.001	.004	3	3
BREAST	HPS6 →	+0.126	+0.759	.005	.001	3	3
BREAST	GPR141 →	+0.188	+0.914	<.001	<.001	3	3
LIVER	ZNF439 →	+0.207	+0.246	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CPLANE2 by Camera-type eye photoreceptor cell differentiation activity — PANCREAS

Explore this box plot interactively →