Camera-type eye photoreceptor cell differentiation

Across TCGA cell cohorts, RNA activity of the Camera-type eye photoreceptor cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CARS1, GBE1, and KCNJ2, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Camera-type eye photoreceptor cell differentiation activity versus CARS1 in LUNG_SCLC (Pearson r = 0.68).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	CARS1 →	+0.619	+1.107	.003	.002	3	1
LUNG_SCLC	GBE1 →	-1.180	-1.740	.002	<.001	3	1
LUNG_SCLC	KCNJ2 →	-0.974	-1.361	.003	<.001	3	1
LUNG_SCLC	ADCK2 →	+0.769	+1.224	<.001	<.001	3	1
LUNG_SCLC	KRBA1 →	+0.851	+1.203	.001	.006	3	1
LUNG_SCLC	ERP27 →	-0.248	-1.456	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060219 vs CARS1 — LUNG_SCLC

Explore this scatter interactively →