Hematopoietic stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Hematopoietic stem cell differentiation pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are C1QC, C1R, and FAM83H_S914, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell differentiation activity versus C1QC in CCRCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	C1QC →	+0.622	+0.032	<.001	<.001	3	6
CCRCC	C1R →	+0.530	+0.032	<.001	<.001	3	6
LSCC	FAM83H_S914 →	-0.535	-0.037	<.001	<.001	3	6
HNSC	EPN3 →	-0.629	-0.078	<.001	<.001	3	6
HNSC	ESRP2_S573 →	-0.517	-0.070	.001	.001	3	6
HNSC	ESRP2 →	-0.539	-0.078	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060218 vs C1QC — CCRCC

Explore this scatter interactively →