Hematopoietic stem cell differentiation

Across TCGA patient cohorts, RNA activity of the Hematopoietic stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TAF4B, LYAR, and SNPH, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell differentiation activity versus TAF4B in OV (Pearson r = 0.07).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TAF4B →	+0.573	+0.677	<.001	<.001	3	4
OV	LYAR →	+0.489	+0.527	.001	.007	3	4
GBM	SNPH →	-0.679	-0.232	.001	.006	3	4
GBM	DKC1 →	+0.328	+0.238	.003	.008	3	4
UCEC	SGSM1 →	+0.450	+0.324	.009	.006	3	3
BRCA	USF1P1 →	-0.191	-0.399	.005	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060218 vs TAF4B — OV

Explore this scatter interactively →