Hematopoietic stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Hematopoietic stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CDKN1A, EDA2R, and SESN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CDKN1A grouped by Hematopoietic stem cell differentiation-low versus -high activity in OVARY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CDKN1A →	-3.336	-1.507	<.001	<.001	3	7
CNS	EDA2R →	-1.826	-1.107	.002	.002	3	7
SKIN	SESN1 →	-0.842	-0.995	.001	<.001	3	7
SKIN	RRM2B →	-1.125	-1.035	<.001	.006	3	6
LUNG_NSCLC_LUAD	RPS19 →	-0.483	-1.073	.002	.001	3	6
SKIN	GDF15 →	-3.356	-1.037	<.001	.002	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CDKN1A by Hematopoietic stem cell differentiation activity — OVARY

Explore this box plot interactively →