Hematopoietic stem cell differentiation

Across TCGA cell cohorts, RNA activity of the Hematopoietic stem cell differentiation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRPS1, CGB2, and IQSEC2, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Hematopoietic stem cell differentiation activity versus TRPS1 in LUNG_NSCLC_LUAD (Pearson r = -0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	TRPS1 →	-1.819	-0.282	.004	.001	3	2
LUNG_NSCLC_LUAD	CGB2 →	+2.880	+0.282	.001	.001	3	2
LUNG_NSCLC_LUAD	IQSEC2 →	-1.943	-0.282	.004	.001	3	2
LUNG_NSCLC_LUAD	ARHGEF4 →	-2.453	-0.282	.008	.001	3	2
LUNG_NSCLC_LUAD	GAREM1 →	-1.569	-0.260	.006	.008	3	2
LUNG_NSCLC_LUAD	FOXO1 →	-0.816	-0.282	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060218 vs TRPS1 — LUNG_NSCLC_LUAD

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