Definitive hemopoiesis

Across TCGA patient cohorts, RNA activity of the Definitive hemopoiesis pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN2, CNRIP1, and NAA10, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Definitive hemopoiesis activity versus TLN2 in LSCC (Pearson r = 0.31).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	TLN2 →	+0.541	+0.053	<.001	<.001	3	8
BRCA	CNRIP1 →	+0.584	+0.053	<.001	<.001	3	8
BRCA	NAA10 →	-0.310	-0.044	<.001	<.001	3	8
CCRCC	G3BP1 →	-0.098	-0.044	.002	<.001	3	8
UCEC	AGO1 →	+0.285	+0.083	<.001	<.001	3	7
BRCA	DNAJC7 →	-0.388	-0.056	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060216 vs TLN2 — LSCC

Explore this scatter interactively →