Definitive hemopoiesis

Across TCGA patient cohorts, RNA activity of the Definitive hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TMEM200A, IGFL2, and RPSAP76, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Definitive hemopoiesis activity versus TMEM200A in COAD (Pearson r = -0.20).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	TMEM200A →	-1.074	-0.658	<.001	.004	3	4
BRCA	IGFL2 →	-0.603	-0.316	.006	.004	2	4
COAD	RPSAP76 →	-0.104	-0.482	<.001	.005	3	3
GBM	APOC1 →	-1.175	-0.699	<.001	.001	3	3
OV	SAMSN1-AS1 →	-0.140	-0.705	.006	<.001	3	3
OV	GRASLND →	-0.774	-0.808	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060216 vs TMEM200A — COAD

Explore this scatter interactively →