Definitive hemopoiesis

Across TCGA cell cohorts, RNA activity of the Definitive hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LCMT1, TMEM125, and ELMO3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, LCMT1 grouped by Definitive hemopoiesis-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	LCMT1 →	-0.414	-0.819	.003	.001	3	5
OVARY	TMEM125 →	-3.009	-0.824	.001	.006	3	5
BLOOD_Leukemia	ELMO3 →	-0.517	-1.187	.005	<.001	3	4
URINARY_TRACT	TMEM62 →	-0.889	-2.007	<.001	<.001	2	4
URINARY_TRACT	C1QTNF2 →	+1.163	+1.682	.001	<.001	3	3
URINARY_TRACT	USP43 →	-1.418	-1.682	.003	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

LCMT1 by Definitive hemopoiesis activity — CNS

Explore this box plot interactively →