Definitive hemopoiesis

Across TCGA cell cohorts, RNA activity of the Definitive hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RANGAP1, DCAF11, and GMEB2, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Definitive hemopoiesis activity versus RANGAP1 in PANCREAS (Pearson r = 0.90).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	RANGAP1 →	+0.592	+1.381	.001	<.001	3	1
PANCREAS	DCAF11 →	-0.592	-1.381	.004	<.001	3	1
PANCREAS	GMEB2 →	+0.816	+1.451	<.001	<.001	3	1
PANCREAS	SYP →	+0.415	+1.280	.003	.002	3	1
PANCREAS	GPI →	+1.104	+1.381	.005	<.001	3	1
PANCREAS	NRF1 →	+0.524	+1.381	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060216 vs RANGAP1 — PANCREAS

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