Primitive hemopoiesis

Across TCGA patient cohorts, RNA activity of the Primitive hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the TGCT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are GATA2, TMED10P2, and GATA2-AS1, each associated with the pathway in up to 26 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primitive hemopoiesis activity versus GATA2 in TGCT (Pearson r = 0.51).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
TGCT	GATA2 →	+2.233	+0.070	<.001	<.001	3	26
CHOL	TMED10P2 →	+1.566	+0.050	<.001	<.001	3	23
CHOL	GATA2-AS1 →	+1.550	+0.040	.002	.006	1	24
UVM	STK3 →	+0.870	+0.049	<.001	<.001	3	20
STAD	ARHGAP39 →	+0.749	+0.038	<.001	<.001	3	19
UVM	MTERF3 →	+1.031	+0.036	<.001	<.001	3	19

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060215 vs GATA2 — TGCT

Explore this scatter interactively →