Primitive hemopoiesis

Across TCGA patient cohorts, RNA activity of the Primitive hemopoiesis pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SEMA4B, CARMIL1_S122, and BOP1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primitive hemopoiesis activity versus SEMA4B in PDAC (Pearson r = 0.16).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SEMA4B →	+0.446	+0.043	.001	.007	3	6
LSCC	CARMIL1_S122 →	+0.594	+0.041	<.001	.001	3	6
HNSC	BOP1 →	+0.227	+0.053	<.001	<.001	3	6
HNSC	DRG1 →	+0.235	+0.064	<.001	<.001	3	6
HNSC	KIF23 →	+0.459	+0.056	<.001	<.001	3	6
LSCC	CCDC134 →	+0.369	+0.057	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060215 vs SEMA4B — PDAC

Explore this scatter interactively →