Primitive hemopoiesis

Across TCGA patient cohorts, RNA activity of the Primitive hemopoiesis pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TNFSF13B, VN1R21P, and MIR222HG, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Primitive hemopoiesis activity versus TNFSF13B in GBM (Pearson r = 0.14).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	TNFSF13B →	+0.465	+0.158	.001	.006	3	3
LSCC	VN1R21P →	-0.751	-0.792	.003	.003	3	3
COAD	MIR222HG →	+0.666	+0.687	.002	<.001	3	3
LUAD	PVT1 →	+0.521	+0.450	.007	.008	3	3
LUAD	MYOM2 →	-0.390	-0.569	<.001	.001	3	3
UCEC	MYBL1 →	+0.391	+0.649	.008	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060215 vs TNFSF13B — GBM

Explore this scatter interactively →