Regulation of nuclear-transcribed mRNA poly(A) tail shortening

Across TCGA patient cohorts, RNA activity of the Regulation of nuclear-transcribed mRNA poly(A) tail shortening pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, MTA1, and RIN1, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nuclear-transcribed mRNA poly(A) tail shortening activity versus UCHL1 in LSCC (Pearson r = 0.27).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	UCHL1 →	+0.894	+0.031	.006	.008	3	6
LSCC	MTA1 →	+0.422	+0.052	<.001	<.001	3	6
LSCC	RIN1 →	-0.641	-0.043	<.001	.001	3	5
HNSC	S100A16 →	-0.709	-0.095	<.001	<.001	3	5
HNSC	SAE1 →	+0.267	+0.080	.001	<.001	3	5
LSCC	SF3B3 →	+0.267	+0.059	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060211 vs UCHL1 — LSCC

Explore this scatter interactively →