Regulation of nuclear-transcribed mRNA poly(A) tail shortening

Across TCGA patient cohorts, RNA activity of the Regulation of nuclear-transcribed mRNA poly(A) tail shortening pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RNA5SP35, NUTF2P5, and KCNQ1, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nuclear-transcribed mRNA poly(A) tail shortening activity versus RNA5SP35 in HNSC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNA5SP35 →	+0.654	+0.405	.002	<.001	3	3
UCEC	NUTF2P5 →	-0.328	-0.478	.007	.001	3	3
UCEC	KCNQ1 →	-0.539	-0.403	.009	.007	3	3
GBM	DENND3 →	-0.612	-0.736	.008	.003	3	3
GBM	C9orf106 →	-0.651	-0.808	<.001	<.001	3	3
GBM	LINC01374 →	-0.822	-0.929	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060211 vs RNA5SP35 — HNSC

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