Regulation of nuclear-transcribed mRNA poly(A) tail shortening

Across TCGA cell cohorts, RNA activity of the Regulation of nuclear-transcribed mRNA poly(A) tail shortening pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PABPC1, TLX3, and KLK10, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PABPC1 grouped by Regulation of nuclear-transcribed mRNA poly(A) tail shortening-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	PABPC1 →	-0.276	-1.275	.002	.003	2	9
BLOOD_Myeloma	TLX3 →	+0.297	+1.880	.006	.003	3	5
STOMACH	KLK10 →	+0.155	+0.297	<.001	.009	3	5
BREAST	SLU7 →	-0.264	-0.620	<.001	.004	3	5
BREAST	SF3B2 →	+0.358	+0.572	<.001	<.001	3	5
LIVER	PPP2R3A →	+0.335	+1.666	.003	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PABPC1 by Regulation of nuclear-transcribed mRNA poly(A) tail shortening activity — PANCREAS

Explore this box plot interactively →