Regulation of nuclear-transcribed mRNA poly(A) tail shortening

Across TCGA cell cohorts, RNA activity of the Regulation of nuclear-transcribed mRNA poly(A) tail shortening pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TTC25, TFPT, and ZFP3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TTC25 grouped by Regulation of nuclear-transcribed mRNA poly(A) tail shortening-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	TTC25 →	-0.509	-0.862	<.001	.002	3	4
BLOOD_Lymphoma	TFPT →	-1.225	-0.549	<.001	.006	3	3
BLOOD_Lymphoma	ZFP3 →	-0.710	-0.455	.003	.005	3	3
LARGE_INTESTINE	RUNX2 →	-1.047	-0.702	.009	.002	3	3
LIVER	GHITM →	-0.617	-1.135	.007	.004	3	3
STOMACH	RNF113A →	+0.656	+0.369	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TTC25 by Regulation of nuclear-transcribed mRNA poly(A) tail shortening activity — LARGE_INTESTINE

Explore this box plot interactively →