Regulation of nuclear-transcribed mRNA poly(A) tail shortening

Across TCGA cell cohorts, RNA activity of the Regulation of nuclear-transcribed mRNA poly(A) tail shortening pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MRPL28, KARS1, and ACTR2, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of nuclear-transcribed mRNA poly(A) tail shortening activity versus MRPL28 in BREAST (Pearson r = 0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MRPL28 →	+0.501	+0.460	<.001	.006	3	6
UPPER_AERODIGESTIVE_TRACT	KARS1 →	+0.875	+0.862	<.001	.007	3	4
UPPER_AERODIGESTIVE_TRACT	ACTR2 →	+0.937	+1.145	.002	.004	2	5
UPPER_AERODIGESTIVE_TRACT	CMC2 →	+1.045	+1.054	<.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	MTPN →	+0.742	+1.078	.001	<.001	3	4
UPPER_AERODIGESTIVE_TRACT	VDAC1 →	+1.128	+0.865	.004	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060211 vs MRPL28 — BREAST

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