Positive regulation of lipase activity

Across TCGA patient cohorts, RNA activity of the Positive regulation of lipase activity pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MPHOSPH10, CSE1L, and MAP4K1, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of lipase activity activity versus MPHOSPH10 in LSCC (Pearson r = 0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	MPHOSPH10 →	-0.260	-0.038	<.001	<.001	3	9
LSCC	CSE1L →	-0.345	-0.043	<.001	<.001	3	9
GBM	MAP4K1 →	+0.415	+0.056	.001	<.001	3	9
OV	RSU1 →	+0.441	+0.033	<.001	<.001	3	8
LSCC	TGM2 →	+0.678	+0.061	<.001	<.001	3	8
COAD	TLN1 →	+0.375	+0.028	.001	.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060193 vs MPHOSPH10 — LSCC

Explore this scatter interactively →