Positive regulation of lipase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipase activity pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are BCAM, EEF1A1, and TGFA, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, BCAM grouped by Positive regulation of lipase activity-low versus -high activity in SKIN.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	BCAM →	-1.315	-1.055	.009	.004	3	5
LUNG_NSCLC_LUAD	EEF1A1 →	+0.638	+1.044	<.001	<.001	3	4
LUNG_NSCLC_LUAD	TGFA →	-1.521	-0.831	<.001	<.001	3	4
BLOOD_Leukemia	MARCHF8 →	+1.300	+1.393	.002	<.001	3	4
OESOPHAGUS	MROH6 →	-2.166	-1.342	.004	.003	3	4
LUNG_NSCLC_LUAD	CUL7 →	+0.673	+0.643	<.001	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

BCAM by Positive regulation of lipase activity activity — SKIN

Explore this box plot interactively →