Positive regulation of lipase activity

Across TCGA cell cohorts, RNA activity of the Positive regulation of lipase activity pathway is significantly associated with the drug response of multiple features, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Lapatinib, AGI-6780, and CPI-613, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Lapatinib grouped by Positive regulation of lipase activity-low versus -high activity in BONE.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Lapatinib →	-0.713	-1.359	.008	.002	3	2
SOFT_TISSUE	AGI-6780 →	-0.805	-0.294	.025	.038	2	3
SOFT_TISSUE	CPI-613 →	+0.553	+0.348	.012	.031	3	2
SOFT_TISSUE	FTY-720 →	+0.186	+0.348	.015	.031	3	2
OVARY	Bleomycin (50 uM) →	-1.824	-0.201	.022	.031	3	2
OESOPHAGUS	GSK2830371 →	-0.404	-0.358	.022	.010	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Lapatinib by Positive regulation of lipase activity activity — BONE

Explore this box plot interactively →