Regulation of lipase activity

pathway activity — cross-omics
GO:0060191Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Regulation of lipase activity pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ADPRH, RSU1, and UTP14A, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
HNSCADPRH →+0.474+0.042<.001<.00139
COADRSU1 →+0.479+0.024.001.00138
LSCCUTP14A →-0.336-0.037<.001<.00138
OVRENBP →+0.514+0.039<.001<.00138
OVBZW2 →-0.339-0.028.006.00338
OVCLIC2 →+0.591+0.038<.001<.00138
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration