Limb bud formation

Across TCGA cell cohorts, RNA activity of the Limb bud formation pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MILR1, ZNF837, and HABP4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MILR1 grouped by Limb bud formation-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MILR1 →	+2.791	+0.721	<.001	.007	3	4
BLOOD_Lymphoma	ZNF837 →	+0.865	+1.688	.002	.007	3	3
LIVER	HABP4 →	+1.754	+1.335	.001	.002	3	3
LIVER	DERL1 →	+0.777	+0.939	.001	.003	3	3
PANCREAS	SMARCAD1 →	-0.589	-1.025	.003	.006	3	3
URINARY_TRACT	ID3 →	-2.763	-1.207	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MILR1 by Limb bud formation activity — PANCREAS

Explore this box plot interactively →