Limb bud formation

Across TCGA cell cohorts, RNA activity of the Limb bud formation pathway is significantly associated with the drug response of multiple features, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated features across cancer lineages are Taselisib, GSK-LSD1, and Fulvestrant, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, Taselisib grouped by Limb bud formation-low versus -high activity in UPPER_AERODIGESTIVE_TRACT.

Pathway-associated features by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner feature	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Taselisib →	+1.212	+0.746	.005	<.001	3	1
UPPER_AERODIGESTIVE_TRACT	GSK-LSD1 →	+0.523	+0.798	.028	.001	3	1
UPPER_AERODIGESTIVE_TRACT	Fulvestrant →	-0.614	-1.016	.012	.005	3	1
UPPER_AERODIGESTIVE_TRACT	AGK2 →	+0.681	+0.798	.028	.001	3	1
UPPER_AERODIGESTIVE_TRACT	AT-7519 →	-1.295	-1.016	<.001	.005	3	1
UPPER_AERODIGESTIVE_TRACT	Pelitinib →	-0.440	-0.664	.039	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Taselisib by Limb bud formation activity — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →