Positive regulation of dopamine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of dopamine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are STRBP, ZYX, and AHNAK2_S3408, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dopamine receptor signaling pathway activity versus STRBP in BRCA (Pearson r = -0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	STRBP →	-0.437	-0.071	<.001	<.001	3	6
UCEC	ZYX →	+0.426	+0.080	.002	.004	3	6
BRCA	AHNAK2_S3408 →	+0.721	+0.054	<.001	<.001	3	6
COAD	EHD1 →	+0.289	+0.055	<.001	.008	3	6
COAD	PIP4K2A →	+0.348	+0.060	<.001	<.001	3	6
BRCA	NUMB_S438 →	+0.524	+0.054	<.001	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060161 vs STRBP — BRCA

Explore this scatter interactively →