Positive regulation of dopamine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of dopamine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are LINC02555, C3, and USP37, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of dopamine receptor signaling pathway activity versus LINC02555 in LUAD (Pearson r = 0.44).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	LINC02555 →	+0.668	+0.343	<.001	<.001	3	4
LSCC	C3 →	+0.702	+0.413	.001	<.001	3	4
LSCC	USP37 →	-0.328	-0.359	<.001	.001	3	4
LSCC	ABCA8 →	+0.764	+0.502	<.001	<.001	3	4
LUAD	LINC02471 →	+0.611	+0.314	<.001	<.001	3	4
LSCC	RPS26P31 →	+0.502	+0.510	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060161 vs LINC02555 — LUAD

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