Positive regulation of dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Positive regulation of dopamine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MTAP, ANKRD10, and CYRIB, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MTAP grouped by Positive regulation of dopamine receptor signaling pathway-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	MTAP →	-4.026	-0.912	<.001	.003	3	4
OESOPHAGUS	ANKRD10 →	+0.884	+0.339	.004	<.001	3	3
BLOOD_Myeloma	CYRIB →	+1.394	+0.337	.003	.007	3	3
LARGE_INTESTINE	PRMT5 →	-0.720	-0.825	.001	.007	3	3
LARGE_INTESTINE	IL17RD →	-1.267	-0.897	<.001	<.001	3	3
LARGE_INTESTINE	SGCB →	-0.876	-0.776	.007	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MTAP by Positive regulation of dopamine receptor signaling pathway activity — PANCREAS

Explore this box plot interactively →