Regulation of dopamine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of dopamine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are EHD2, KANK2, and RSU1, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dopamine receptor signaling pathway activity versus EHD2 in OV (Pearson r = 0.46).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	EHD2 →	+1.028	+0.059	<.001	.002	3	10
UCEC	KANK2 →	+0.756	+0.085	<.001	.002	3	10
UCEC	RSU1 →	+0.550	+0.115	<.001	<.001	3	9
UCEC	TLN1 →	+0.496	+0.106	<.001	<.001	3	9
UCEC	PARVA →	+0.616	+0.086	.002	.001	3	9
PDAC	SYNPO →	+0.430	+0.083	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060159 vs EHD2 — OV

Explore this scatter interactively →