Regulation of dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of dopamine receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRMT5, RGS8, and DNAJC17, each associated with the pathway in up to 11 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PRMT5 grouped by Regulation of dopamine receptor signaling pathway-low versus -high activity in CNS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRMT5 →	-0.752	-1.558	<.001	<.001	3	11
BLOOD_Leukemia	RGS8 →	-0.417	-1.650	.005	.003	3	9
LUNG_NSCLC_LUSC	DNAJC17 →	-0.282	-1.527	.002	.001	3	6
KIDNEY	DTNBP1 →	-0.234	-1.517	<.001	<.001	3	5
LUNG_NSCLC_LUAD	STK39 →	+0.124	+0.993	.002	<.001	3	5
SKIN	PALM →	-0.527	-2.125	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PRMT5 by Regulation of dopamine receptor signaling pathway activity — CNS

Explore this box plot interactively →