Regulation of dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of dopamine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CSRP2, SYTL2, and ITGB5, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CSRP2 grouped by Regulation of dopamine receptor signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	CSRP2 →	-1.666	-0.835	.002	.002	3	5
OESOPHAGUS	SYTL2 →	+2.437	+1.488	<.001	<.001	3	5
UPPER_AERODIGESTIVE_TRACT	ITGB5 →	+1.353	+1.570	.004	<.001	3	5
CNS	SSC5D →	+1.951	+0.979	.005	.005	3	4
BREAST	HENMT1 →	+1.960	+1.031	.004	.001	3	4
PANCREAS	NMU →	-2.366	-1.265	.007	.007	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CSRP2 by Regulation of dopamine receptor signaling pathway activity — LARGE_INTESTINE

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