Regulation of dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of dopamine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the CNS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRRG4, LIG3, and LSM12, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of dopamine receptor signaling pathway activity versus PRRG4 in CNS (Pearson r = -0.47).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	PRRG4 →	-0.810	-0.963	.003	.008	2	4
BLOOD_Myeloma	LIG3 →	+0.406	+0.232	.002	<.001	3	3
LUNG_NSCLC_LUAD	LSM12 →	+0.380	+0.588	<.001	.003	3	3
OVARY	QRSL1 →	+0.491	+0.601	.001	.002	3	3
OVARY	PRRC2B →	+1.082	+0.829	.001	.003	3	3
OVARY	PMPCA →	+0.811	+0.572	.001	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060159 vs PRRG4 — CNS

Explore this scatter interactively →