Phospholipase C-activating dopamine receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Phospholipase C-activating dopamine receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are NIBAN2_S696, NMI, and CUX1_S562, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Phospholipase C-activating dopamine receptor signaling pathway activity versus NIBAN2_S696 in OV (Pearson r = -0.05).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	NIBAN2_S696 →	+0.661	+0.073	.006	.002	3	6
GBM	NMI →	+0.484	+0.140	<.001	<.001	3	6
GBM	CUX1_S562 →	+0.375	+0.120	<.001	<.001	3	6
GBM	TBC1D2 →	+0.396	+0.139	.001	<.001	3	5
GBM	UBE4A →	-0.165	-0.096	.004	.003	3	5
GBM	ADNP →	-0.281	-0.108	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060158 vs NIBAN2_S696 — OV

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