Phospholipase C-activating dopamine receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Phospholipase C-activating dopamine receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CFAP61, SELENOP, and ICAM1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CFAP61 grouped by Phospholipase C-activating dopamine receptor signaling pathway-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	CFAP61 →	+0.493	+0.978	.004	.002	3	5
BREAST	SELENOP →	+2.872	+0.754	<.001	.008	2	5
OVARY	ICAM1 →	-2.852	-1.013	.002	.006	2	5
KIDNEY	TBP →	-0.605	-1.489	.005	<.001	3	4
BONE	NUP43 →	-0.785	-1.258	.001	.003	3	4
BLOOD_Leukemia	PTMS →	-1.940	-0.729	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CFAP61 by Phospholipase C-activating dopamine receptor signaling pathway activity — BREAST

Explore this box plot interactively →