Platelet dense granule organization

Across TCGA patient cohorts, RNA activity of the Platelet dense granule organization pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RASAL3, GZMK, and SLAMF1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet dense granule organization activity versus RASAL3 in GBM (Pearson r = 0.37).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	RASAL3 →	+0.688	+0.149	<.001	<.001	3	5
HNSC	GZMK →	+1.020	+0.129	.002	.008	3	5
HNSC	SLAMF1 →	+0.952	+0.168	<.001	.001	3	5
HNSC	FUT7 →	+0.613	+0.122	.009	.008	3	5
GBM	NELFCD →	-0.353	-0.140	.001	<.001	3	4
GBM	ATP8B4 →	+0.826	+0.144	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060155 vs RASAL3 — GBM

Explore this scatter interactively →