Platelet dense granule organization

Across TCGA patient cohorts, RNA activity of the Platelet dense granule organization pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are FMNL1_S184, AIF1_S39, and NAIP, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet dense granule organization activity versus FMNL1_S184 in HNSC (Pearson r = 0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	FMNL1_S184 →	+0.783	+0.184	<.001	<.001	3	4
OV	AIF1_S39 →	+1.187	+0.156	<.001	<.001	3	4
GBM	NAIP →	+0.495	+0.102	<.001	<.001	3	4
GBM	PTPN7 →	+0.416	+0.135	<.001	<.001	3	4
COAD	HPS5 →	+0.897	+0.322	<.001	<.001	3	3
COAD	NSD3 →	-0.467	-0.147	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060155 vs FMNL1_S184 — HNSC

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