Negative regulation of post-transcriptional gene silencing

Across TCGA patient cohorts, RNA activity of the Negative regulation of post-transcriptional gene silencing pathway is significantly associated with the protein abundance of multiple proteins, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are VDAC2_T68, IDE, and PGAM1_S31, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of post-transcriptional gene silencing activity versus VDAC2_T68 in HNSC (Pearson r = -0.13).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	VDAC2_T68 →	-0.642	-0.092	.001	.007	3	4
HNSC	IDE →	-0.286	-0.118	<.001	<.001	3	4
HNSC	PGAM1_S31 →	-0.495	-0.082	<.001	<.001	3	4
LSCC	STK11IP_S599 →	+0.467	+0.067	<.001	<.001	3	4
LSCC	TP53 →	+1.021	+0.062	<.001	<.001	3	4
CCRCC	HTT_S1864 →	-0.888	-0.066	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060149 vs VDAC2_T68 — HNSC

Explore this scatter interactively →