Negative regulation of post-transcriptional gene silencing

Across TCGA patient cohorts, RNA activity of the Negative regulation of post-transcriptional gene silencing pathway is significantly associated with the RNA expression of multiple genes, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are H4C10P, NXT1-AS1, and SUCLG2, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of post-transcriptional gene silencing activity versus H4C10P in LSCC (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	H4C10P →	+0.817	+0.183	<.001	.001	3	4
HNSC	NXT1-AS1 →	+0.526	+0.177	<.001	<.001	3	3
BRCA	SUCLG2 →	-0.553	-0.269	<.001	.001	3	3
OV	CNTNAP3 →	+0.489	+0.259	.007	.008	3	3
OV	TP53 →	+0.768	+0.245	.007	.003	3	3
GBM	LINC00322 →	-0.201	-0.134	.003	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0060149 vs H4C10P — LSCC

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