Negative regulation of post-transcriptional gene silencing

Across TCGA cell cohorts, RNA activity of the Negative regulation of post-transcriptional gene silencing pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MAP2K6, TPM1, and CD9, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, MAP2K6 grouped by Negative regulation of post-transcriptional gene silencing-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	MAP2K6 →	+0.792	+0.359	.009	.005	3	3
LARGE_INTESTINE	TPM1 →	+0.820	+0.565	.003	.004	3	3
CNS	CD9 →	+1.316	+0.469	<.001	.003	3	2
CNS	YWHAE →	+0.765	+0.799	<.001	.002	3	2
CNS	NUP42 →	+0.450	+0.446	.002	.005	3	2
CNS	TBRG4 →	+0.440	+0.613	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

MAP2K6 by Negative regulation of post-transcriptional gene silencing activity — BREAST

Explore this box plot interactively →